Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation.

Although the mechanisms that contribute to intracranial aneurysm (IA) formation and rupture are not totally elucidated, inflammation and matrix remodeling are incriminated. Because tPA (tissue-type plasminogen activator) controls both inflammatory and matrix remodeling processes, we hypothesized that tPA could be involved in the pathophysiology of IA.

• Publication date: Sep 2017
• Journal: Stroke
• Publication date: Labeyrie PE, Goulay R, Martinez de Lizarrondo S, Hébert M, Gauberti M, Maubert E, Delaunay B, Gory B, Signorelli F, Turjman F, Touzé E, Courthéoux P, Vivien D, Orset C
• ISSN: 1524-4628