Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates.

Secondary microthrombosis is a major pathophysiologic mechanism leading to brain damage following transient mechanical vascular occlusion (TMVO), the most widely used experimental stroke model. Whether secondary microthrombosis also occurs in non-TMVO stroke models represents an important issue for clinical translation of antimicrothrombosis therapeutic strategies.

• Publication date: 2014
• Journal: Journal of thrombosis and haemostasis : JTH
• Publication date: Gauberti M, Martinez de Lizarrondo S, Orset C, Vivien D
• ISSN: 1538-7836