Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.

Patients with major depressive disorder (MDD) can present with altered brain structure and deficits in cognitive function similar to those seen in aging. However, the interaction between age-related brain changes and brain development in MDD remains understudied. In a cohort of adolescents and adults with and without MDD, we assessed brain aging differences and associations through a newly developed tool that quantifies normative neurodevelopmental trajectories.

• Publication date: Aug 2024
• Journal: Biological psychiatry. Cognitive neuroscience and neuroimaging
• Publication date: Ho NCW, Bethlehem RAI, Seidlitz J, Nogovitsyn N, Metzak P, Ballester PL, Hassel S, Rotzinger S, Poppenk J, Lam RW, Taylor VH, Milev R, , Bullmore ET, Alexander-Bloch AF, Frey BN, Harkness KL, Addington J, Kennedy SH, Dunlop K
• ISSN: 2451-9030