Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia.

To investigate whether global and regional beta-amyloid (Abeta) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD).

• Publication date: Jan 2010
• Journal: Neurology
• Publication date: Bourgeat P, Chételat G, Villemagne VL, Fripp J, Raniga P, Pike K, Acosta O, Szoeke C, Ourselin S, Ames D, Ellis KA, Martins RN, Masters CL, Rowe CC, Salvado O,
• ISSN: 1526-632X