Preclinical evidence toward the use of ketamine for recombinant tissue-type plasminogen activator-mediated thrombolysis under anesthesia or sedation.

Endovascular treatment of ischemic stroke usually involves recombinant tissue-type plasminogen activator (rtPA)-mediated thrombolysis in anesthetized patients. Paradoxically, differential influences of anesthetic agents on thrombolysis outcome remain unknown.

• Publication date: Oct 2011
• Journal: Stroke
• Publication date: Gakuba C, Gauberti M, Mazighi M, Defer G, Hanouz JL, Vivien D
• ISSN: 1524-4628