Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.

The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.

• Publication date: Mar 2013
• Journal: Nature reviews. Neurology
• Publication date: Chételat G
• ISSN: 1759-4766